Mouse models for sporadic cancer

Much of the advancement in mouse models for cancer during the past 2 decade s can be attributed to our increasing capacity to specifically modify the m ouse germ line. The first generations of oncomice and tumor-suppressor gene knockouts are now being succeeded by regulatable or conditional mouse tumo r models, which can be utilized more effectively to establish correlations between distinct genetic lesions and specific tumor characteristics and to design and improve therapeutic intervention strategies. In this review we t ry to ave the reader a flavor of how the latest reagents can be utilized. ( C) 2001 Academic Press.