Allogeneic stem cell transplantation for acute lymphocytic leukemia in adults

This is a comprehensive review evaluating the use of allogeneic stem cell t ransplantation as treatment for adults with acute lymphocytic leukemia (ALL ). The results of allogeneic transplantation for patients in first complete remission, with advanced ALL or with Philadelphia chromosome-positive ALL, are described. The data regarding available preparative regimens and the u se of peripheral blood stem are presented. The controversies regarding alte rnative donor transplantation, the variety of stem cell sources available, and the timing of transplantation are explained. Lastly, the results from d onor lymphocyte infusions and the future use of immunoconjugates before and after transplantation are illustrated.