Alkylation of some pyrimidine and purine derivatives using microwave-assisted methods

Authors
Rodriguez, H Perez, R Suarez, M Lam, A Cabrales, N Loupy, A
Citation
H. Rodriguez et al., Alkylation of some pyrimidine and purine derivatives using microwave-assisted methods, HETEROCYCLE, 55(2), 2001, pp. 291-301
Citations number
35
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
55
Issue
2
Year of publication
2001
Pages
291 - 301
Database
ISI
SICI code
0385-5414(20010201)55:2<291:AOSPAP>2.0.ZU;2-4
Abstract
N-Alkylation of adenine (1), guanine (2) and 6-amino-2-thiouracil (3) with different halides has been carried out using microwave-assisted methods in the presence of small amounts of DMF to improve energy transfer and in the case of 3 by coupling with phase transfer catalysis. The results obtained s how high yields and selectivities.