It is important that the effects of work on mental health are investig
ated when work practices are changing rapidly and there is decreasing
job security. This has been examined in the Whitehall II Study, a coho
rt study of 6895 male and 3413 female, London-based civil servants, ag
ed 35-55 years at baseline in 1985. Work characteristics were measured
by modified Karasek indices in a self-report questionnaire: Psychiatr
ic disorder was measured by the 30-item General Health Questionnaire (
GHQ). In longitudinal analyses in men and women, high work social supp
ort predicted lower GHQ scores, and high job demands predicted higher
GHQ scores at follow-up. High work social support and high skill discr
etion were protective against taking short spells of psychiatric sickn
ess absence. The protective effects of social support at work and the
potential risk of job demands have implications for management, job de
sign, training, and further research. (C) 1997 Elsevier Science Inc.