beta-Adrenergic receptor blockers and weight gain - A systematic analysis

One of the arguments put forward against the primary use of P-blockers has been concern about adverse metabolic effects, such as unfavorable effects o n lipids or insulin sensitivity. Another less-appreciated potential drawbac k is their propensity to cause weight gain in some patients, In 8 evaluable prospective randomized controlled trials that lasted greater than or equal to6 months, body weight was higher in the beta -blocker than in the contro l group at the end of the study. The median difference in body weight was 1 .2 kg (range -0.4 to 3.5 kg), A regression analysis suggested that beta -bl ockers were associated with an initial weight gain during the first few mon ths. Thereafter, no further weight gain compared with controls was apparent . There was no relationship between demographic characteristics and changes in body weight. Based on these observations, the first-line use of beta -b lockers in obese hypertensive patients should be reviewed. Obesity manageme nt in overweight hypertensive patients may be more difficult in the face of beta -blocker treatment.