Xw. Sun et al., Synthesis of 1,3,4-thiadiazole, 1,2,4-triazole and 1,3,4-oxadiazole derivatives containing 1-(p-chlorophenyl)-5-methyl-1,2,3-triazol-4-yl moiety, I J CHEM B, 40(1), 2001, pp. 15-19
Citations number
8
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
2-Aroylamino-5-[1-(p-chlorophenyl)-5-methyl-1,2,3-triazol-4-yl]-1,3,4-thiad
iazoles 3a-e and 3-[1-(p-chlorophenyl)-5-methyl-1,2,3-triazol-4-yl]-1,2,4-t
riazole-5(4H)-thione 4 have been synthesized by the cyclization of 4-aroyl-
1-[1-(p-chlorophenyl)-5-methyl-1,2,3-triazole-4-carbonyl]thiosemicarbazides
2a-e with cone. H2SO4 and 2N NaOH solution, respectively. Moreover, 2-aryl
-5-[1-(p-chlorophenyl)-5-methyl-1,2,3-triazol-4-yl]-1,3,4-oxadiazoles 7a-e
have been obtained by the direct condensation of 1-(p-chlorophenyl)-5-methy
l-1,2,3-triazole-4-carbohydrazide with aromatic acids in the presence of PO
Cl3. All the compounds synthesized have been characterized by their element
al analyses and spectral data.