Simple synthesis of 5-substituted thiouracil has been achieved by the chlor
osulphonation to give 2-thiouracil-5-sulphonylchloride 2 which then heated
with primary amines to give the amides 3a-c. Compound 2 on treatment with p
-amino-acetophenone and p-hydroxyacetophenone furnishes respectively 4 and
5 while with hydrazine 6 is obtained. Compound 2 on reaction with secondary
amines namely morpheline, N-methylpiperazine and diethylamine respectively
furnishes 12a-c. All the compounds have been characterized by IR and NMR s
pectra.