Synthesis of some new thiouracil derivatives with expected biological activity

Simple synthesis of 5-substituted thiouracil has been achieved by the chlor osulphonation to give 2-thiouracil-5-sulphonylchloride 2 which then heated with primary amines to give the amides 3a-c. Compound 2 on treatment with p -amino-acetophenone and p-hydroxyacetophenone furnishes respectively 4 and 5 while with hydrazine 6 is obtained. Compound 2 on reaction with secondary amines namely morpheline, N-methylpiperazine and diethylamine respectively furnishes 12a-c. All the compounds have been characterized by IR and NMR s pectra.