Synthesis of pyrazolines and cyanopyridines as potential antimicrobial agents

3,3'-Bis-(4-acetophenylaminosulphonyl)benzophenone 1 on condensation with v arious aldehydes yields chalcones 2a-p which on cyclization with hydrazine hydrate and malononitrile furnishes the corresponding 3,3'-bis-(5-aryl-1H/a cetylpyrazolin-3-yl-4-phenylaminosulphonyl)benzophenones 3a-p,3'a-p and 3,3 '-bis-(2 amino-3-cyano-4-aryl pyridin-6-yl-4-phenylaminosulphonyl)benzophen ones 4a-p. The structure of the compounds have been confirmed from elementa l analyses, IR, H-1 NMR and mass spectral data. All the products have been evaluated for their in vitro growth inhibitory activity against different m icrobes.