Y. Cavusoglu et al., Evaluation of C-reactive protein, fibrinogen and antithrombin-III as risk factors for coronary artery disease, ISR MED ASS, 3(1), 2001, pp. 13-16
Background: inflammation is an important feature of atherosclerotic lesions
and increased production of the acute-phase reactant. The contribution of
coagulation factor to the development of coronary artery disease has not ye
t been clearly established.
Objectives: To test whether C-reactive protein, fibrinogen and antithrombin
-III are associated with angiographic CAD, history of myocardial infarction
and extensive atherosclerotic involvement.
Methods: Blood samples were tested for CRP, fibrinogen and AT-III levels fr
om 219 individuals undergoing coronary angiography.
Results: CRP was higher in patients with CAD (0.95 +/- 1.31, n = 180, vs. 0
.39 +/- 0.61 mg/dl, n = 39, P < 0.0001) and in those with a history of MI (
1.07 +/- 1.64, n = 96, vs. 0.65 +/- 0.72 mg/dl, n = 84, P < 0.05) than in c
ontrol subjects. The patients who developed unstable angina had higher CRP
levels than the patients with stable CAD (2.07 +/- 2.38, n = 7, vs. 0.80 +/
- 1.13 mg/dl, n = 173, P < 0.001). Fibrinogen was significantly higher in p
atients with CAD than in those without CAD (298 +/- 108 vs. 258 +/- 63 mg/d
l, P < 0.01). In patients with CAD. mean AT-III value was less than in pati
ents without CAD, but this difference was not statistically significant (P
= 0.08). No difference was found in CRP, fibrinogen and ATIII values among
the patients with single, double or triple vessel disease.
Conclusions: CRP is elevated in patients with CAD and a history of MI. Elev
ated levels of CRP at the time of hospital admission is a predictive value
for future ischemic events. There is an association between higher levels o
f fibrinogen and CAD. The association of AT-III levels with CAD needs testi
ng in further studies.