Antinociceptive effect of vitamin K-2 (menatetrenone) in diabetic mice

Authors
Onodera, K Zushida, K Kamei, J
Citation
K. Onodera et al., Antinociceptive effect of vitamin K-2 (menatetrenone) in diabetic mice, JPN J PHARM, 85(3), 2001, pp. 335-337
Citations number
10
Categorie Soggetti
Pharmacology & Toxicology
Journal title
JAPANESE JOURNAL OF PHARMACOLOGY
ISSN journal
00215198 → ACNP
Volume
85
Issue
3
Year of publication
2001
Pages
335 - 337
Database
ISI
SICI code
0021-5198(200103)85:3<335:AEOVK(>2.0.ZU;2-J
Abstract
The antinociceptive effect of vitamin K-2 (menatetrenone) in diabetic mice was examined using a tail-pressure test. Intraperitoneal injection of menat etrenone (10-100 mg/kg) produced a dose-dependent increase in the nocicepti ve threshold in diabetic mice. There was no significant difference between non-diabetic and diabetic mice in the menatetrenone-induced changes in the nociceptive threshold. The results suggest the therapeutical usefulness of menatetrenone for treating painful diabetic neuropathy and osteoporosis.