FosB, a cysteine-dependent fosfomycin resistance protein under the controlof sigma(W), an extracytoplasmic-function sigma factor in Bacillus subtilis

Authors
Cao, M Bernat, BA Wang, ZP Armstrong, RN Helmann, JD
Citation
M. Cao et al., FosB, a cysteine-dependent fosfomycin resistance protein under the controlof sigma(W), an extracytoplasmic-function sigma factor in Bacillus subtilis, J BACT, 183(7), 2001, pp. 2380-2383
Citations number
22
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF BACTERIOLOGY
ISSN journal
00219193 → ACNP
Volume
183
Issue
7
Year of publication
2001
Pages
2380 - 2383
Database
ISI
SICI code
0021-9193(200104)183:7<2380:FACFRP>2.0.ZU;2-#
Abstract
We demonstrate that the Bacillus subtilis fosB(yndN) gene encodes a fosfomy cin resistance protein. Expression of fosB requires sigma (W), and both fos B and sigW mutants are fosfomycin sensitive. FosB is a metallothiol transfe rase related to the FosA class of Mn2+-dependent glutathione transferases b ut with a preference for Mg2+ and L-cysteine as cofactors.