Microdialysis of salicylic acid from viscous emulsion samples prior to high-performance liquid chromatographic determination

A micro-dialysis method was developed to isolate aqueous salicylic acid fro m viscous emulsion samples prior to HPLC determination. The optimal conditi ons for obtaining dialysis efficiency of salicylic acid as well as chromato graphic conditions were investigated. Experimental results indicated that t he dialysis achieved at pH 2.0 (0.025 M phosphate solution), 0.5 M NaCl add ition, and 50-mul/min flow-rate of perfusion stream offered an optimal resu lt. The proposed method provided a simple procedure for isolating salicylic acid from viscous emulsion samples. Application was illustrated by the ana lysis of salicylic acid in cosmetic products. (C) 2001 Elsevier Science BN. All rights reserved.