Convenient substitution of hydroxypyridines with trifluoroacetaldehyde ethyl hemiacetal

Authors
Gong, Y Kato, K Kimoto, H
Citation
Y. Gong et al., Convenient substitution of hydroxypyridines with trifluoroacetaldehyde ethyl hemiacetal, J HETERO CH, 38(1), 2001, pp. 25-28
Citations number
31
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
0022152X → ACNP
Volume
38
Issue
1
Year of publication
2001
Pages
25 - 28
Database
ISI
SICI code
0022-152X(200101/02)38:1<25:CSOHWT>2.0.ZU;2-1
Abstract
Thermal substitution of 4-hydroxypyridine 1 with trifluoroacetaldehyde ethy l hemiacetal (TFAE) leads to a moderate yield of 3-(1-hydroxy-2,2,2-trifluo roethyl)-4-hydroxypyridine 7 in the presence of a catalytic amount of anhyd rous potassium carbonate. Under similar conditions, several alpha -trifluor omethyl hydroxypyridinemethanols 8-15 are easily prepared from 2- or 3-hydr oxypyridines 2-6.