Metalation and halogen-metal exchange in the imidazo[1,2-a]quinoxaline series

Authors
Parra, S Vitse, O Benezech, V Deleuze-Masquefa, C Subra, G Bompart, J Escale, R Chapat, JP Bonnet, PA
Citation
S. Parra et al., Metalation and halogen-metal exchange in the imidazo[1,2-a]quinoxaline series, J HETERO CH, 38(1), 2001, pp. 41-44
Citations number
14
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
0022152X → ACNP
Volume
38
Issue
1
Year of publication
2001
Pages
41 - 44
Database
ISI
SICI code
0022-152X(200101/02)38:1<41:MAHEIT>2.0.ZU;2-#
Abstract
The n-butyllithium and lithium 2,2,6,6-tetramethylpiperidide metalation and the halogen-metal exchange of imidazo[1,2-a]quinoxaline derivatives follow ed by quenching with various electrophiles were studied. The reaction condi tions have been optimized and various C-1 substituted imidazo[1,2-a]quinoxa lines were obtained in high yields.