Preparation of 4-substituted 3-amino-2-chloropyridines, synthesis of a Nevirapine analogue

Authors
Bakke, JM Riha, J
Citation
Jm. Bakke et J. Riha, Preparation of 4-substituted 3-amino-2-chloropyridines, synthesis of a Nevirapine analogue, J HETERO CH, 38(1), 2001, pp. 99-104
Citations number
15
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
0022152X → ACNP
Volume
38
Issue
1
Year of publication
2001
Pages
99 - 104
Database
ISI
SICI code
0022-152X(200101/02)38:1<99:PO43SO>2.0.ZU;2-J
Abstract
A new method for preparing 3-amino-2-chloropyridines with a substituent (me thyl, phenyl, carboxamide, methoxycarbonyl, acetyl, benzoyl and cyano) at t he 4-position has been developed. An isoquinoline analogue of the reverse t ranscriptase inhibitor Nevirapine has been synthesized from the 4-amino-3-c hloroisoquinoline.