M. Venugopal et al., Synthesis and antimicrobial activity of 2-substituted-2,3-dihydro-5-propoxy-1H-1,3,2-benzodiazaphosphole 2-oxides, J HETERO CH, 38(1), 2001, pp. 275-279
Several 2-alkylcarbamato/thiocarbamato/aryloxy/trichloromethyl-2,3-dihydro-
5-propoxy-1H-1,3,2- benzodiazaphosphole 2-oxides (4 and 6) were synthesised
by reacting 4-propoxy-o-phenylenediamine (1) with various N-dichlorophosph
inyl carbamates (3), aryl phosphorodichloridates (5a-f) and trichloromethyl
phosphonic dichloride (5g) in the presence of triethylamine at 45-65 degre
esC. Their ir, H-1, C-13, P-31 and mass spectral data are discussed. The co
mpounds were screened for antifungal activity against Curvularia lunata and
Aspergillus niger and for antibacterial activity against Bacillus subtilis
and Escherichia coli. Most of these compounds exhibited moderate activity
in the assays.