Jm. Jeong et al., N,N ',N '',N '''-tetraalkylcyclam derivatives: Synthesis, Tc-99m-labelling, and biological properties, J LABEL C R, 44(4), 2001, pp. 277-285
We synthesized N,N ' ,N " ,N ' ' ' -tetraalkylcyclam derivatives in which a
lkyl groups were ethyl, propyl, butyl, methoxyethyl, and ethoxyethyl. We at
tempted to label the compounds with Tc-99m. The cyclams with methyl, ethyl,
and propyl could be labelled. The labelled N,N ' ,N " ,N ' ' ' -tetraalkyl
cyclam derivatives showed +1 charge. They excreted rapidly through the kidn
ey in mice. The liver-uptake increased slightly as the lipophilicity increa
sed. However, the myocardial uptake was low unlikely with the +1 charged my
ocardial imaging agents.