Jr. Lynch et al., Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response, J NEUROIMM, 114(1-2), 2001, pp. 107-113
Apolipoprotein E (apoE) is a 299 amino acid protein that is associated with
risk of developing Alzheimer's Disease (AD) and outcome after acute brain
injury. To investigate the possibility that apoE modulates glial activation
we studied the effect of endogenous apoE on inflammatory gene regulation i
n vitro and in vivo. Our results indicate that apoE downregulates CNS produ
ction of TNF alpha, Il-1 beta, and Il-6 mRNA following stimulation with lip
opolysaccharide (LPS). This effect of endogenous apoE on inflammatory gene
regulation appears to be specific, and may account for the biological role
that apoE plays in acute and chronic human neurological disease. (C) 2001 E
lsevier Science B.V. All rights reserved.