Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response

Citation
Jr. Lynch et al., Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response, J NEUROIMM, 114(1-2), 2001, pp. 107-113
Citations number
38
Categorie Soggetti
Neurosciences & Behavoir
Journal title
JOURNAL OF NEUROIMMUNOLOGY
ISSN journal
01655728 → ACNP
Volume
114
Issue
1-2
Year of publication
2001
Pages
107 - 113
Database
ISI
SICI code
0165-5728(20010301)114:1-2<107:AEMGAA>2.0.ZU;2-O
Abstract
Apolipoprotein E (apoE) is a 299 amino acid protein that is associated with risk of developing Alzheimer's Disease (AD) and outcome after acute brain injury. To investigate the possibility that apoE modulates glial activation we studied the effect of endogenous apoE on inflammatory gene regulation i n vitro and in vivo. Our results indicate that apoE downregulates CNS produ ction of TNF alpha, Il-1 beta, and Il-6 mRNA following stimulation with lip opolysaccharide (LPS). This effect of endogenous apoE on inflammatory gene regulation appears to be specific, and may account for the biological role that apoE plays in acute and chronic human neurological disease. (C) 2001 E lsevier Science B.V. All rights reserved.