Efficacy of Lactobacillus GG in prevention of nosocomial diarrhea in infants

Objective: Nosocomial diarrhea is a major problem in pediatric hospitals wo rldwide. We evaluated the efficacy of orally administered Lactobacillus GG (LGG) in the prevention of this disease in young children. Study design: Eighty-one children aged 1 to 36 months who were hospitalized for reasons other than diarrhea were enrolled in a double-blind trial and randomly assigned at admission to receive LGG (n = 45) at a dose of 6 x 10( 9) colony-forming units or a comparable placebo (n = 36) twice daily orally for the duration of their hospital stay. Results: LGG reduced the risk of nosocomial diarrhea (greater than or equal to3 loose or watery stools/24 h) in comparison with placebo (6.7% vs 33.3% ; relative risk: 0.2; [95% CI: 0.06-0.6]; number needed to treat: ii [95% C I: 2-10]). The prevalence of rotavirus infection was similar in LGG and pla cebo groups (20% vs 27.8%, respectively; relative risk: 0.72; 95% CI: 0.33- 1.56). However, the use of LGG compared with placebo significantly reduced the risk of rotavirus gastroenteritis (1/45 [2.2%] vs 6/36 [16.7%], respect ively; relative risk: 0.13; 95% CI: 0.02-0.79; number needed to treat: 7; 9 5% CI: 3-40). Conclusions: Prophylactic use of LGG significantly reduced the risk of noso comial diarrhea in infants, particularly nosocomial rotavirus gastroenterit is.