Postictal cerebrospinal fluid abnormalities in children

Objectives: To determine the frequency and characteristics of seizure-induc ed cerebrospinal fluid (CSF) abnormalities in children and to identify pote ntial alternative causes of these findings. Methods: Consecutive patients (n = 80) who underwent lumbar puncture within 24 hours after a seizure were studied retrospectively. The presence of CSF abnormalities in total leukocytes, polymorphonuclear cells, and protein wa s determined by using age-specific reference values. Coexisting conditions that could affect CSF findings, such as traumatic lumbar puncture, concurre nt neurologic disease, and undiagnosed meningitis, were identified. Results: Eighteen of the 80 patients were excluded from the final study gro up because of the presence of another condition that could alter the CSF. M ore than 50% of the excluded patients had an abnormal CSF leukocyte count o r protein level, including 2 patients with initially undiagnosed meningitis , which was subsequently detected by post-hoc polymerase chain reaction tes ting. In the remaining 62 patients, postictal pleocytosis was detected in o nly 3 (5%), and increased protein was detected in only 6 (10%). The maximal postictal pleocytosis and protein level were 8 x 10(6) leukocytes/L (8 leu kocytes/mm(3)) and 0.52 g/L (52 mg/dL), respectively. Conclusions: Seizure-induced CSF abnormalities are rare in children, and al ternative, often unidentified, disease processes may account for many obser ved postictal abnormalities. All patients with abnormal CSF after a seizure should be thoroughly evaluated for other causes of the abnormality.