LIPASE-CATALYZED KINETIC RESOLUTION OF PHENYLCYCLOHEXANONE OXIME ESTERS

Authors
MURAKATA M IMAI M TAMURA M HOSHINO O
Citation
M. Murakata et al., LIPASE-CATALYZED KINETIC RESOLUTION OF PHENYLCYCLOHEXANONE OXIME ESTERS, Tetrahedron : asymmetry, 5(10), 1994, pp. 2019-2024
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
5
Issue
10
Year of publication
1994
Pages
2019 - 2024
Database
ISI
SICI code
0957-4166(1994)5:10<2019:LKROPO>2.0.ZU;2-T
Abstract
Formation of optically active alpha or gamma-phenylcyclohexanone oxime s (2a and 2b, c) and their esters (1a and 3b, c) by lipase mediated tr ansesterification of the corresponding racemic esters is described. Fu rthermore, 2(S)-phenyl and 2,2-dimethyl-4(R)-phenylcyclohexanones (4 a nd 5) were prepared without any racemization by treatment with dimethy ldioxirane in acetone or sodium hydrogen sulfite in refluxing aqueous ethanol.