Objective: Psychological factors have been implicated as potentially contri
buting to asthma severity. In the present study, we investigated whether pa
tients with mild and severe asthma differ with regard to several psychologi
cal characteristics. Methods: Ninety outpatients with severe asthma (74% fe
male, mean [S.D.] age: 46.5 [13.7] years) and 37 outpatients with mild asth
ma (73% female, age: 39.4 [13.9] years) were compared with respect to gener
al psychological health, anxiety sensitivity, hyperventilation symptoms, pe
rsonality, and locus-of-control orientation, all measured by well-validated
self-report questionnaires. Analysis of (co)variance (ANCOVA) was used to
assess between-groups differences. Results: No significant differences in p
sychological characteristics were found between patients with mild and seve
re asthma. Only on the subscale for external locus-of-control orientation,
severe asthmatic patients differed from those with mild disease (P=.005) in
showing less trust in physicians and medication with regard to influencing
their asthma. Conclusion: The results suggest that mild and severe asthmat
ic patients cannot be differentiated on the basis of psychopathology or per
sonality Whether or not the observed lack of confidence in the influence of
physicians or medication on asthma course is cause or consequence of disea
se severity, remains to be established. (C) 2001 Elsevier Science Inc. All
rights reserved.