Transcription factors and translocations in lymphoid and myeloid leukemia

Chromosomal translocations involving transcription factors and aberrant exp ression of transcription factors are frequently associated with leukemogene sis. Transcription factors are essential in maintaining the regulation of c ell growth, development, and differentiation in the hematopoietic system. A lterations in the mechanisms that normally control these functions can lead to hematological malignancies. Further characterization of the molecular b iology of leukemia will enhance our ability to develop disease-specific tre atment strategies, and to develop effective methods of diagnosis and progno sis.