CEPU-1 expression in the early embryonic chick brain

We describe the expression pattern of CEPU-1, a cell adhesion molecule of t he immunoglobulin superfamily, in the early chick embryo brain. An initiall y broad domain of expression. encompassing forebrain, midbrain and anterior hindbrain, is subsequently narrowed down to a ring-shaped domain at the mi dbrain-hindbrain boundary, cu-localizing precisely with the expression of W nt1 at the isthmus. In addition, CEPU-1 is expressed in the dorsal aspect o f rhombomere 4 and its emigrating neural crest cells. Later in development, we also find CEPU-1 expression in other parts of the developing nervous sy stem such as sensory ganglia and in the ventral aspect of forebrain, midbra in and hindbrain. (C) 2001 Elsevier Science Ireland Ltd. All rights reserve d.