CLINICAL-RESPONSES AND PLATINUM CONCENTRATIONS IN TUMORS AFTER INTRAARTERIAL AND INTRAVENOUS ADMINISTRATION OF CISPLATIN IN THE SAME PATIENTS WITH CERVICAL-CANCER

We evaluated 3 patients with advanced cervical cancer treated with cis platin intra-arterially and intravenously. The dose of cisplatin was 5 0 mg/m(2) in each infusion. Chemotherapy was repeated at 4-week interv als for three to four courses. The clinical response and the tumor con centration of platinum were evaluated in each course. All patients who received the intra-arterial infusion of cisplatin were judged to be r esponders, whereas none of them responded to the intravenous infusion. The platinum concentration in tumor tissue was significantly higher a fter intra-arterial infusion of cisplatin (1.97 +/- 0.04 vs. 2.86 +/- 0.10 mu g/g). Although there were no apparent differences in side effe cts between intra-arterial and intravenous routes, 2 of 3 patients rej ected an intra-arterial route. The present study suggests that intra-a rterial administration of cisplatin may be useful in treating locally advanced cervical cancer.