TREATMENT OF METASTATIC UTERINE LEIOMYOSARCOMA WITH CISPLATIN, PIRARUBICIN, AND IFOSFAMIDE

We present the unusual case of a 27-year-old Japanese woman who exhibi ted recurrences of metastatic tumors from uterine leiomyosarcoma after five operations. Chemotherapy with cisplatin, pirarubicin, and cyclop hosphamide was ineffective. Substituting ifosfamide for cyclophosphami de, we obtained a complete response. The Gynecologic Oncology Group (G OG) in the United States has recognized the efficacy of ifosfamide and mesna in the treatment of patients with advanced or recurrent uterine sarcomas. Here we report on the efficacy of ifosfamide in addition to cisplatin and pirarubicin.