Acetyl-L-carnitine enhances Na+, K+-ATPase glutathione-s-transferase and multiple unit activity and reduces lipid peroxidation and lipofuscin concentration in aged rat brain regions

Authors
Kaur, J Sharma, D Singh, R
Citation
J. Kaur et al., Acetyl-L-carnitine enhances Na+, K+-ATPase glutathione-s-transferase and multiple unit activity and reduces lipid peroxidation and lipofuscin concentration in aged rat brain regions, NEUROSCI L, 301(1), 2001, pp. 1-4
Citations number
18
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE LETTERS
ISSN journal
03043940 → ACNP
Volume
301
Issue
1
Year of publication
2001
Pages
1 - 4
Database
ISI
SICI code
0304-3940(20010323)301:1<1:AENKGA>2.0.ZU;2-5
Abstract
This study investigated the effects of chronically administered acetyl-F-ca rnitine (ALC) on sodium potassium adenosine triphosphatase (Na+, K+-ATPase) , glutathione-s-transferase (GST), glutathione peroxidase (GPx), multiple u nit activity (MUA) and lipid peroxidation (LP) and lipofuscin (LF) concentr ation in brain regions: cerebral cortex, hippocampus, striatum and thalamus , of 24-month-old rats. The activity of Na+, K+-ATPase and GST was enhanced ; that of GPx was unaffected. The MUA was increased while the levels of LP and LF were decreased. These novel data provide new additional evidence con cerning the antiaging attributes of ALC. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.