Activation of CB1 cannabinoid receptors in rat hippocampal slices inhibitspotassium-evoked cholecystokinin release, a possible mechanism contributing to the spatial memory defects produced by cannabinoids

Authors
Beinfeld, MC Connolly, K
Citation
Mc. Beinfeld et K. Connolly, Activation of CB1 cannabinoid receptors in rat hippocampal slices inhibitspotassium-evoked cholecystokinin release, a possible mechanism contributing to the spatial memory defects produced by cannabinoids, NEUROSCI L, 301(1), 2001, pp. 69-71
Citations number
17
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE LETTERS
ISSN journal
03043940 → ACNP
Volume
301
Issue
1
Year of publication
2001
Pages
69 - 71
Database
ISI
SICI code
0304-3940(20010323)301:1<69:AOCCRI>2.0.ZU;2-S
Abstract
Cannabinoid use is known to disrupt learning and memory in a number of spec ies. cholecystokinin (CCK) release and CCK receptors have been implicated i n spatial memory processes in rodents. Rat hippocampal CCK interneurons exp ress cannabinoid 1 receptors (CB1). The CB1 agonist R(+)WIN 55,212-2 (WIN ), at 1 and 10 mu mol, strongly inhibited potassium-evoked CCK release from rat hippocampal slices, while the inactive isomer S(-)WIN,55,212-3 (WIN -) had no effect. CCK release from cerebral cortical slices was not altered b y WIN +. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.