Isotopes and accelerators, hallmarks of nuclear physics, are finding increa
singly sophisticated and effective applications in the medical field. Diagn
ostic and therapeutic uses of radioisotopes are now a $10B/yr business worl
dwide, with over 10 million procedures and patient studies performed every
year. This paper will discuss the use of isotopes for these applications. I
n addition, beams of protons and heavy ions are being more and more widely
used clinically for treatment of malignancies. To be discussed here as well
will be the rationale and techniques associated with charged-particle ther
apy, and the progress in implementation and optimization of these technolog
ies for clinical use.