CHROMOPHOBE CELL RENAL-CARCINOMA - DNA FLOW-CYTOMETRY AND PROLIFERATION STATUS IN 9 CASES

Nine cases of chromophobe cell renal carcinoma are reported, 2 in preg nant women, One neoplasm progressed and the patient died of disease, a nd this tumor presented the highest mitotic index and focal positivity to Ki-67 antibody, DNA flow-cytometric study discovered 89 % of aneup loidy, with 3 tetraploid cases, We conclude that chromophobe cell rena l carcinoma is a relatively indolent but clearly malignant neoplasm, W e suggest that the mitotic index could be the best method to predict m alignant behavior, The high incidence of aneuploid cell lines may be d ue to structural anomalies; it is not indicative of malignant behavior .