Synthesis of a 3,4,5-trimethoxybenzoyl ester analogue of epigallocatechin-3-gallate (EGCG): A potential route to the natural product green tea catechin, EGCG

[GRAPHICS] The synthesis of a trimethoxybenzoyl ester (D-ring) analogue of epigallocat echin-3-gallate (EGCG) is described. The versatile synthesis route can be u sed to synthesize A, B, and D ring analogues of EGCG and involves a key cyc lization of the chalcone to the 3-flavene. This synthesis provides a possib le route to the polyphenolic green tea natural product EGCG.