A strategy for probing the autonomy of cross-domain stereochemical communication in glycoconjugates

Authors
Live, DH Wang, ZG Iserloh, U Danishefsky, SJ
Citation
Dh. Live et al., A strategy for probing the autonomy of cross-domain stereochemical communication in glycoconjugates, ORG LETT, 3(6), 2001, pp. 851-854
Citations number
26
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
6
Year of publication
2001
Pages
851 - 854
Database
ISI
SICI code
1523-7060(20010322)3:6<851:ASFPTA>2.0.ZU;2-2
Abstract
[GRAPHICS] Glycoproteins contain carbohydrate and peptide sectors. As a model for stud ying whether there exists stereochemical "communication" between the two do mains, we prepared two glycopeptides differing only in the absolute stereoc hemistry of the peptide domain (L-peptide vs D-peptide), High-field NMR spe ctroscopy revealed that there are distinct and measurable differences, indi cating that the two domains are at some level interactive.