A novel multicomponent synthesis of polysubstituted 5-aminooxazole and itsnew scaffold-generating reaction to pyrrolo[3,4-b]pyridine

[GRAPHICS] A novel three-component synthesis of 5-amino oxazole (1) is reported. Its s ubsequent reaction with ag unsaturated acyl chloride leads to polysubstitut ed pyrrolopyridine (2), A triple domino process, acylation/IMDA/retro-Micha el cycloreversion, was involved in the latter process. The methodology allo ws the quick preparation, from simple and readily available inputs, of high ly functionalized title compounds not easily accessed by other methods.