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Ring closing metathesis of diallylglycine 6 provided cyclic Z-olefin 7 in 8
0% yield, The reaction was promoted by substitution of the amide nitrogen w
ith the 2,4-dimethoxybenzyl group allowing for the required cis diallylglyc
ine amide rotamer, Removal of the protecting groups provided cyclic dipepti
de 2, a constrained scaffold useful in peptidomimetic research.