Expression of the voltage-dependent chloride channel CIC-3 in human nasal tissue

Authors
Oshima, T Ikeda, K Furukawa, M Suzuki, H Takasaka, T
Citation
T. Oshima et al., Expression of the voltage-dependent chloride channel CIC-3 in human nasal tissue, ORL-J OTO R, 63(2), 2001, pp. 82-86
Citations number
16
Categorie Soggetti
Otolaryngology
Journal title
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES
ISSN journal
03011569 → ACNP
Volume
63
Issue
2
Year of publication
2001
Pages
82 - 86
Database
ISI
SICI code
0301-1569(200103/04)63:2<82:EOTVCC>2.0.ZU;2-T
Abstract
In the present study, CIC-3, one of the voltage-dependent chloride channels , was identified in human nasal tissue. In situ hybridization and immunohis tochemical investigations demonstrated the localization of CIC-3 in the ser ous acini and ductal portions of submucosal nasal glands, which are the pri mary source of nasal secretion. Our data suggest that this channel contribu tes to nasal secretion via chloride transport. Its dysfunction might lead t o abnormal nasal secretion in such pathological states as sinusitis. Copyri ght (C) 2001 S. Karger AG, Basel.