Objective: Recent studies have shown that transtympanic gentamicin for Meni
ere's syndrome is effective. Current treatment protocols vary. One concept
has been to perform a chemical ablation; the other has been to perform a ch
emical alteration. Ablation requires multiple injections and is effective i
n controlling the vertigo, but it is associated with a significant incidenc
e of hearing loss. Chemical alteration uses a minimal dose to reduce vestib
ular function without affecting cochlear function.
Study Design: Prospective.
Setting: Tertiary medical center.
Patients: Patients had classic unilateral Meniere's syndrome that was unres
ponsive to medical therapy.
Intervention: A single injection of gentamicin is given, and the patient is
seen 1 month after injection. If indicated, the patient receives another i
njection and is reevaluated I month later.
Main Outcome Measures: Control of vertigo and maintenance of hearing using
the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HhTS) gui
delines (1995).
Results: Fifty-six patients have documented follow-up for 2 years or more,
and 21 have 4 years or more of follow-up. This article presents the 4-year
results as outlined by the AAO-HNS guidelines. Vertigo classes A and B were
seen in 82% of patients. The patients followed 2 to 4 years had 86% vertig
o class A and B results. Those followed 4 years or more show 76% with a ver
tigo class A or B result. In this study there has been minimal cochlear los
s. There was vestibular change clinically, which was documented by electron
ystagmography.
Conclusions: It appears that a single transtympanic gentamicin injection is
effective in controlling the vertigo of Meniere's syndrome. Cochlear impac
t has been minimal. It is most useful for those patients who have failed me
dical management and are severely affected but not totally incapacitated by
the disease.