Neurophysiologic exploration: A reliable tool in HIV-1 encephalopathy diagnosis in children

Background. HIV-1 related encephalopathy has a bad prognostic meaning in th e course of AIDS disease, but the early association of different drugs can modify its course. For this reason it is very important to recognize CNS in volvement as soon as possible. As shown in the literature, at least in adul t studies, EEG and Evoked Potentials (EP) are good tools in evaluating CNS alterations, In children data are rare. Methods. A ten-year prospective study of 44 infected children out of 142 bo rn from HIV-1 positive mothers has been done. The children have been submit ted to EEG recording every six months in the first 18 months of life and th en every year, to multimodal EP every six months. A total of 357 EEG, 47 P- VEP, 62 F-VEP and 98 BAEP have been performed. Results. EEG: we found no pathologic results in patients belonging to categ ory A; results were pathologic in 17.7% in category B, in 47.7% in C and in 77% of encephalopathic patients, It seems that EEG alterations are paralle l to disease progression, with a relative risk of developing encephalopathy (R.R.=1.15) and of death (R.R.=2.33) for patients belonging to category C. We obtained a statistically significant lengthening in BAEP interpeak late ncy of left ear in all groups. For patients in category C the risk of devel oping encephalopathy is statistically significant (p=0.045; R.R.=6.75) and risk of death is high (R.R.=4), Conclusions. Neurophysiologic exams are a reliable tool for the diagnosis o f encephalopathy, in addition to clinical evidence.