LANGERHANS CELL HISTIOCYTOSIS ASSOCIATED WITH GRAVES-SYNDROME IN AN ADOLESCENT

Background. - Immunological dysfunction is known to be present in Lang erhans cell histiocytosis; some autoimmune diseases with autoantibodie s associated with this condition have already been described. This imm unological dysfunction could play a role in the Langerhans cell histio cytosis pathogenesis. Case report. - A 13 year-old boy presented a mul tifocal bone Langerhans cell histiocytosis associated with Graves' syn drome. This last condition was successfully treated with carbimazole w hile the local lesions of histiocytosis did not require any treatment. Conclusion. - This unique association could be explained by the immun ological dysfunction seen in Langerhans cell histiocytosis with second ary appearance of thyreostimulating antibodies.