Three experiments were conducted to assess the effects on broiler breeders
of contamination of feed with the ionophore anticoccidial semduramicin. In
Experiment 1, individually caged females received 0,12.5, or 25 mg/kg diet
for 3 wk from 48 to 50 wk of age. In Experiment 2, males and females in flo
or pens received 0, 12.5, or 25 mg/kg diet for 3 wk from 63 to 65 wk of age
. In Experiment 3, individually caged males and females received 0, 3, 6, o
r 25 mg/kg diet for 1 wk at 31 Wk Of age and were mated by artificial insem
ination. There was a dose-related decrease in cumulative egg production and
percentage shell in Experiment 1 after more than 1 wk exposure, but these
effects were not observed in the other experiments. There was a decrease in
cumulative fertile hatchability and a dose-related decrease after 3 wk exp
osure due to an increase in early embryonic mortality in Experiment 2, but
these changes were not observed during the 1-wk exposure in Experiment 3. T
he data show that adverse effects of semduramicin require greater than 1 wk
of exposure to be evident.