Objective: The aim of this investigation was to evaluate the clinical perfo
rmance of 4 types of tooth-colored inlays. Method and materials: Fifteen di
rect ceramic inlays (Cerec Cos 2.0), 15 direct resin composite inlays (Bril
liant Direct Inlay), 14 indirect ceramic inlays (Vita Dur N), and 14 indire
ct resin composite inlays (Estilux) were made in 37 patients, according to
the manufacturers' instructions. The inlays were evaluated 1 week (baseline
) and 6, 12, 36, 48, and 60 months after cementation (modified CDA Quality
Evaluation System). Results: Two Vita Dur N inlays fractured after 1 and 4
years in function, and one Cerec inlay fractured after 4.5 years. Two Brill
iant DI inlays needed replacement because of secondary caries (after 1 and
5 years), and one inlay (Estilux) needed replacement due to persisting hype
rsensitivity. Three inlays (1 Estilux and 2 Brilliant DI) were repaired due
to chipping or minor fractures. During the observation period, the surface
texture of Brilliant DI and Vita Dur N inlays became significantly rougher
. After 5 years, the Estilux inlays had significantly lower ratings for mor
phology compared to baseline ratings. In general, the occlusal marginal ada
ptation did not show further disintegration of the luting cement after 1 ye
ar. Conclusion: Eighty-eight percent of the inlays were in function after 5
years, No significant differences were revealed among the survival rates o
f the different types of inlays.