PHOSPHOINOSITIDE 3-KINASES - A CONSERVED FAMILY OF SIGNAL TRANSDUCERS

Authors
VANHAESEBROECK B LEEVERS SJ PANAYOTOU G WATERFIELD MD
Citation
B. Vanhaesebroeck et al., PHOSPHOINOSITIDE 3-KINASES - A CONSERVED FAMILY OF SIGNAL TRANSDUCERS, Trends in biochemical sciences, 22(7), 1997, pp. 267-272
Citations number
53
Categorie Soggetti
Biology
Journal title
Trends in biochemical sciences → ACNP
ISSN journal
09680004
Volume
22
Issue
7
Year of publication
1997
Pages
267 - 272
Database
ISI
SICI code
0968-0004(1997)22:7<267:P3-ACF>2.0.ZU;2-6
Abstract
Phosphoinositide 3-kinases (PI3Ks) generate lipids that are implicated in receptor-stimulated signalling and in the regulation of membrane t raffic. Several distinct classes of PI3Ks have now been identified tha t have been conserved throughout eukaryotic evolution. Potential signa lling pathways downstream of PI3Ks have been elucidated and PI3K funct ion is now being characterised in several model organisms.