GENETIC-MAPPING OF BOVINE T-CELL RECEPTOR COMPLEX LOCI

Thymic-derived lymphocytes (T cells) recognize and respond to antigens through the mediation of the T-cell receptor complex. Here we report polymorphism at each of the five loci that encode the different compon ents of the T-cell receptor complex in cattle. These genes were mapped on the bovine genome by genetic linkage analysis in the international Bovine Reference Panel (IBRP). These mapping data provide additional type I markers for linking the bovine genetic map with the human and m ouse maps and also permit investigation of the effect of T-cell recept or polymorphism on immune responsiveness and disease susceptibility.