Structure-selectivity studies on catalysts for the phase-transfer catalysed asymmetric alkylation of glycine imine esters

Authors
Lygo, B Crosby, J Lowdon, TR Wainwright, PG
Citation
B. Lygo et al., Structure-selectivity studies on catalysts for the phase-transfer catalysed asymmetric alkylation of glycine imine esters, TETRAHEDRON, 57(12), 2001, pp. 2391-2402
Citations number
37
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
57
Issue
12
Year of publication
2001
Pages
2391 - 2402
Database
ISI
SICI code
0040-4020(20010317)57:12<2391:SSOCFT>2.0.ZU;2-Z
Abstract
In this paper, we describe the synthesis of a series of chiral quaternary a mmonium salts with core structures that are closely related to the cinchona alkaloid, cinchonine. By employing these salts as asymmetric phase-transfe r agents in the benzylation of a glycine imine, an optimal catalyst structu re is identified. (C) 2001 Elsevier Science Ltd. All rights reserved.