Studies on the enantioselective synthesis of alpha-amino acids via asymmetric phase-transfer catalysis

Authors
Lygo, B Crosby, J Lowdon, TR Peterson, JA Wainwright, PG
Citation
B. Lygo et al., Studies on the enantioselective synthesis of alpha-amino acids via asymmetric phase-transfer catalysis, TETRAHEDRON, 57(12), 2001, pp. 2403-2409
Citations number
30
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
57
Issue
12
Year of publication
2001
Pages
2403 - 2409
Database
ISI
SICI code
0040-4020(20010317)57:12<2403:SOTESO>2.0.ZU;2-P
Abstract
In this paper, we describe investigations into the use of cinchona alkaloid -derived quaternary ammonium phase-transfer catalysts for the asymmetric al kylation of a benzophenone-derived glycine-imine. Utility of this process i s demonstrated by the enantioselective synthesis of a range of alpha -amino acid esters. (C) 2001 Elsevier Science Ltd. All rights reserved.