Influence of glycosylation on the conformational preferences of folded oligopeptides

Synthesis, characterization, and conformational analysis by FT-IR absorptio n, H-1 NMR and X-ray diffraction techniques are described for a series of s ide-chain O-glycosylated Thr peptides of different main-chain length rich i n the helicogenic Aib residue. The results obtained, compared with those of related peptides containing side-chain protected Thr and Ser residues and host Aib homo-oligomers, also reported in this work, provided new informati on on the preferred conformation of the naturally occurring antifreeze glyc opeptides. (C) 2001 Elsevier Science Ltd. All rights reserved.