Solid-phase synthesis of oligoesters using a JandaJel (TM) resin

Authors
Brummer, O Clapham, B Janda, KD
Citation
O. Brummer et al., Solid-phase synthesis of oligoesters using a JandaJel (TM) resin, TETRAHEDR L, 42(12), 2001, pp. 2257-2259
Citations number
19
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
12
Year of publication
2001
Pages
2257 - 2259
Database
ISI
SICI code
0040-4039(20010318)42:12<2257:SSOOUA>2.0.ZU;2-4
Abstract
This communication describes a general method for the solid-phase synthesis of oligomeric esters. A JandaJel(TM) resin was utilized as the solid suppo rt in conjunction with the highly acid labile Rink linker. Ester coupling r eactions were performed using buffered reagents and the monomer was protect ed as its allyl ester. In this manner, ester coupling and deprotection coul d be performed under essentially neutral conditions, giving rise to product s in both excellent yields and purity. (C) 2001 Elsevier Science Ltd. All r ights reserved.