Universal Rink-isonitrile resin: application for the traceless synthesis of 3-acylamino imidazo[1,2-a] pyridines

Authors
Chen, JJ Golebiowski, A McClenaghan, J Klopfenstein, SR West, L
Citation
Jj. Chen et al., Universal Rink-isonitrile resin: application for the traceless synthesis of 3-acylamino imidazo[1,2-a] pyridines, TETRAHEDR L, 42(12), 2001, pp. 2269-2271
Citations number
10
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
12
Year of publication
2001
Pages
2269 - 2271
Database
ISI
SICI code
0040-4039(20010318)42:12<2269:URRAFT>2.0.ZU;2-Y
Abstract
Rink resin was converted to isonitrile resin after formylation with HCO2H/d iisopropylcarbodiimide followed by POCl3/diisopropylethylamine dehydration. This polymer-supported isonitrile was then employed in the multi-component synthesis of imidazo[1,2-a]pyridines. The resin-bound imidazo[1,2-a]pyridi ne was acylated and spontaneously released by acyl chloride treatment in di chloroethane. (C) 2001 Elsevier Science Ltd. All rights reserved.