Pd(II) - dppb and syngas catalyze regioselective hydroesterification of terminal alkynes under neutral conditions

Authors
El Ali, B Tijani, J El-Ghanam, AM
Citation
B. El Ali et al., Pd(II) - dppb and syngas catalyze regioselective hydroesterification of terminal alkynes under neutral conditions, TETRAHEDR L, 42(12), 2001, pp. 2385-2387
Citations number
9
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
12
Year of publication
2001
Pages
2385 - 2387
Database
ISI
SICI code
0040-4039(20010318)42:12<2385:P-DASC>2.0.ZU;2-O
Abstract
Palladium(II) regioselectively catalyzes the hydroesterification of termina l alkynes under syngas forming alpha,beta -unsaturated esters 3 and 4 in ex cellent chemical yields under neutral conditions. The high selectivity for the linear ester 4 was obtained with a catalytic system that includes Pd(II ), 1,4-bis(diphenylphosphino)butane (dppb) and CO/H-2 in CH2Cl2 as solvent. The control of the regioselectivity depends strongly upon the type of liga nd, the solvent and the use of the syngas mixture. (C) 2001 Elsevier Scienc e Ltd. All rights reserved.