F. Grellepois et al., Ring-contracted artemisinin derivatives: stereoselective reaction of anhydrodihydroartemisinin towards halogenating reagents, TETRAHEDR L, 42(11), 2001, pp. 2125-2127
Reaction of anhydrodihydroartemisinin 1 with halogenating reagents and furt
her rearrangement of adducts into ring-contracted aldehydes has been revisi
ted. The stereochemistry of reactions with iodine is opposite to that with
bromine, and allowed the preparation of the new aldehyde 4 with conservatio
n of the configuration of starting artemisinin at C-9. (C) 2001 Elsevier Sc
ience Ltd. All rights reserved.