Conformationally restricted glutamic acid derivatives: asymmetric synthesis of 4-substituted 4,5-dihydro-3(2H)-pyridazinones

Authors
Alvarez-Ibarra, C Csaky, AG de la Oliva, CG Rodriguez, E
Citation
C. Alvarez-ibarra et al., Conformationally restricted glutamic acid derivatives: asymmetric synthesis of 4-substituted 4,5-dihydro-3(2H)-pyridazinones, TETRAHEDR L, 42(11), 2001, pp. 2129-2131
Citations number
13
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
11
Year of publication
2001
Pages
2129 - 2131
Database
ISI
SICI code
0040-4039(20010311)42:11<2129:CRGADA>2.0.ZU;2-B
Abstract
The synthesis of optically pure 4,5-dihydro-3(2H)-pyridazinones substituted at C-4, which can be considered conformationally restricted cyclic Glu der ivatives, has been accomplished by the asymmetric gamma -alkylation of alph a,beta -unsaturated glutamyl sultams under PTC conditions followed by react ion with hydrazines. (C) 2001 Elsevier Science Ltd. All rights reserved.